Isotretinoin For Acne Treatment
Isotretinoin is an orally-taken acne treatment used for severe cases of acne. It must be prescribed by physicians who are experts in the use of retinoids in the treatment of severe types of acne (for example, nodular acne or acne that is likely to result in permanent scars) that has not responded to treatment with antibacterials and topical acne treatments, and with an understanding of the potential risks of isotretinoin acne treatments and the requirements for monitoring. Although isotretinoin can be a very effective treatment for severe cases of acne, it has some side effects and its use should be avoided by some people, in particular by women who could possibly be pregnant or are thinking of becoming pregnant.
Isotretinoin is manufactured in 10 mg capsules and 20 mg capsules, under several trade names, including the trade name isotane®. In some other countries, other brands of isotretinoin include accutane®/roaccutane® and the trade name oratane®. Most people undergoing isotretinoin treatment have a course of isotretinoin for between 16 and 30 weeks (between 4 and 7 months), but some people may need it for a longer period of treatment. For some people, continuous treatment can be prescribed for the long term, normally at a low dosage or intermittent periods. If required, it may be prescribed for children in addition to adults. If you have been prescribed isotretinoin it is extremely important to read the instructions and understand how to take the medication. If you are in any doubt or are confused, ask your physician or dermatologist to explain anything you don’t fully understand. Avoid giving your medication to other people. It is extremely important to not start taking the medication if you think you may be or are pregnant, and avoid becoming pregnant while taking the course of treatment as it could potentially cause major birth defects. Do not hesitate to contact your physician or dermatologist if you have any worries about your treatment.
Isotretinoin should be considered to be a toxic drug, but when it has been prescribed and has been monitored properly, it can result in a significant improvement in a patient’s severe acne. However, isotretinoin can potentially cause mucocutaneous, gastrointestinal, ophthalmologic, neuromuscular, rheumatologic and psychiatric side effects, as well as the previously mentioned birth defects. Some of the minor side effects of isotretinoin are dry mouth, and cheilitis. 90% of patients who experience adverse effects on the skin and in the subcutaneous tissues have dry skin, erythematous rash, localised exfoliation, and dermatitis. The likelihood of experiencing these side effects usually increases during the first 4 weeks of undergoing therapy and subsequently diminishes at about week 12 to week 16. Around week 4 of therapy, facial rash and dry skin often occur, possibly with a simultaneous acne flare. Nosebleeds and dry eyes are also commonly experienced. People who normally wear contact lenses may have to avoid wearing them during treatment because of discomfort. Sometimes patients may also have impaired night vision.
